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Severe gastrointestinal disease represents another important contraindication for tirzepatide, particularly in patients with gastroparesis or other conditions causing significant delays in gastric emptying
After crossing the BBB, the GLP-1RA binds to the GLP-1R and mimics the action of the GLP-1 hormone, stimulating the intracellular accumulation of cAMP, which via the action of PKA/RGNEF4 results in neuroprotective effects (10)
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