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Once the cysteine moieties become oxidized, they combine to form cystine
Transketolase is encoded by the TKT gene
Additionally, senescent cells produce matrix metalloproteinases (MMPs) and other proteolytic enzymes that disrupt the extracellular matrix, interfering with normal tissue structure and function
Additionally, endosomal escape is a significant barrier as nucleic acids often become trapped in endosomes and degraded
Winter SC: Treatment of carnitine deficiency
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