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its availability for NAD + synthesis can be partially controlled by modulation of purine nucleotide phosphorylase (PNP), which plays a role in purine salvage pathways where purine bases are recycled into nucleotides 24 and in metabolism of the NAD + precursor nicotinamide riboside (NR) 25

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Finally, although this analysis incorporated more comorbidities than many prior studies, several obesity-related conditions (e.g., certain cancers, osteoarthritis, and mental health disorders) were not included

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