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The peptide is created by the inclusion of 13 amino acids to the N-terminus of native IGF-1 and by replacing the glutamic acid at position 3 with arginine, which ultimately leads to the formation of an 83 amino acid peptide

Thus, ROS/ RNS can be considered key players of immune activation, bloodbrain barrier disruption, vascular failure, neuronal injury, and cochlear damage during pneumococcal meningitis

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