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People who have low B12 levels experience numbness and tingling sensations in their hands and feet

4 In blood diseases like leukemia, polycythemia vera and hypereosinophylic syndrome, the cause is often an enhanced production of the transport protein haptocorrin, to which most of the circulating B12 in blood is bound

The exact timing depends on the patients needs, like how severe the deficiency is and how well they absorb the vitamin

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The critical insight: peptide concentration affects stability