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The application of synthetic cannabinoids (e.g., WIN55,212-2) were able to reduce the microglial release of these factors and directly act on primary astrocyte cells from mice to reduce hemichannel activation, preventing astrocytic uncoupling and maintaining gap junctions (Froger et al., 2009
Both carry a boxed warning about thyroid C-cell tumours based on rodent studies
Contrasting endocrine responses to acute oral compared with intravenous sodium loading in normal humans
IM injections have stricter volume limits: deltoid maximum 1 mL, vastus lateralis 2 mL, ventrogluteal 3 mL
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