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Transgenic or knock out animals of these enzymes (GS, GDH, and SSADH) have provided evidence that they are of significant, functional importance for the maintenance of homeostatic mechanisms related to the cellular contents as well as to the neurotransmitter function
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Investigators monitor parameters such as dendritic spine density, post-synaptic density protein 95 (PSD-95) expression, and neurite outgrowth lengths following treatment across picomolar to nanomolar concentration gradients
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