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Orforglipron, made by the same company that produces the GLP-1 medications Zepbound and Mounjaro (tirzepatide), is an oral medication undergoing FDA clinical tests for use in weight loss
In our study, the relative risk of symptomatic cholelithiasis was 1.6, 1.4, and 0.9 in liraglutide, Semaglutide, and dulaglutide versus control group, with the number needed to harm of 3.14, 5.56, and 16.6, respectively
Anti-HSP70 autoantibodies can be detected in saliva and urine using indirect ELISA, including in healthy individuals, providing a non-invasive biomarker modality with potential utility for disease prediction, early detection, and longitudinal monitoring
Given the potential for GLP-1 RA to affect heart rates [30], a meta-analysis of 43 RCTs using GLP-1 RAs showed no increased risk of AF with GLP-1 RAs [39]
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