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The addition of B12 to compounded semaglutide is a clinical practice decision rather than an evidence-based protocol with its own trial data
Back McLean, BA, Wong, CK, Campbell, JE, et al (2021) 'Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation', Endocrine Reviews , 42/2, 101-32
(Hammer Nutrition Direct, 2019)
It reached Phase II clinical trials for postoperative ileus (a gut-recovery condition) and was discontinued after the trial did not show efficacy
Human G1 and G2 were inserted into a pFastDual plasmid and were prepared by insertion of His 6 -tagged human G 1 fragment (BamHI/HindIII site) under the polh promoter and insertion of G 2 fragment (XhoI/SphI site) under the p10 promoter, respectively (Genewiz)
