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For skin, increasing NAD may improve renewal, resilience, and repair

GHK-Cu is a naturally occurring copper complex of the tripeptide glycyl-L-histidyl-L-lysine, originally isolated by Loren Pickart from human plasma in 1973. The compound is one of the most extensively characterized small peptides in published research, with documented effects on collagen synthesis, glycosaminoglycan production, and approximately 4,000 human gene expression changes

But the skin is an endocrine organ

This route offers potential for future oral or transdermal formulations, but more research is needed before real-world use

I recommend an excellent liver tonic called "Livatone Plus" which contains a combination of herbs, anti-oxidants, B vitamins, minerals and amino acids to support the detoxification pathways in the liver