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Shortterm results of a randomized, doubleblind, sham controlled study

The regulatory gap in the Retatrutide vs Tirzepatide comparison represents both a risk and an opportunity for researchers: Retatrutide offers access to cutting-edge triple agonist biology before commercial availability, but without the safety certainty that FDA approval provides

For F-actin quantification, at the end of experiment, cells were trypsinized than fixed with PBS/ formalin 3% then incubated with PBS/ Triton 0.1%/ TRITC-phallodin 1 g/mL (Sigma Aldrich) during 5 min

The 12mg dose produced greater weight loss but also more GI-related discontinuations