Both tirzepatide and orforglipron can cause gastrointestinal side effects (nausea, vomiting, diarrhea, constipation)
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Dietary adjustments are often the first line of self-management: Eat smaller, more frequent meals rather than large portions Avoid high-fat, greasy, or heavily spiced foods, which can exacerbate loose stools Reduce intake of foods known to cause wind, such as beans, cruciferous vegetables, and carbonated drinks If constipation is the predominant symptom, increase soluble fibre gradually sudden large increases in fibre can worsen bloating and discomfort Stay well hydrated, particularly if experiencing diarrhoea, to prevent dehydration Timing and lifestyle considerations can also make a meaningful difference
N., Dorius, B
These side effects, while manageable in many cases, require careful consideration, especially in patients with pre-existing gastroesophageal issues
