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The catalytic glutamate residue E 115 accepts a proton from the -glutamyl group of the substrate, initiating a nucleophilic attack by the amine on the amide carbon atom

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J Neurochem 105:11441152 Grange E, Gharib A, Lepetit P, Guillaud J, Sarda N, Bobillier P (1992) Brain protein synthesis in the conscious rat using l-[ 35 S]methionine: relationship of methionine specific activity between plasma and precursor compartment and evaluation of methionine metabolic pathways

This review provides a meticulous exploration of GLP-1, elucidating its origin, secretion, and the challenges associated with its clinical application due to its fragility in the presence of DPP-IV, resulting in a short half-life