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In addition to accelerating the loss of metabolically competent hepatocytes and liver function, advanced fibrosis and cirrhosis restrict hepatic blood flow, increasing the risk of acute liver failure, HCC, and liver-related mortality (215)

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Across multiple SURPASS trials, tirzepatide demonstrated A1C reductions ranging from 1.9% to 2.4% from baseline A1C levels of approximately 8.0%, depending on the dose