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Reciprocally, gut microbiota biotransform dietary components to produce various physiologically active metabolites, such as SCFAs, secondary bile acids, and indole derivatives, which enter the liver via the portal venous system and participate in host glucose and lipid metabolism as well as immune regulation ( The concept of the gut-liver-kidney nutritional metabolic axis has gradually emerged and received widespread attention in recent years

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Polyphenolic compounds such as resveratrol and quercetin exert renal protective effects through activation of multiple pathways including Nrf2, AMPK, and SIRT1 (302)