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J Clin Endocrinol Metab 80:13931398 Guevara-Aguirre J, Rosenbloom AL, Vasconez O, Martinez V, Gargosky SE, Allen L, Rosenfeld RG (1997) Two year treatment of growth hormone (GH) receptor deficiency with recombinant insulin-like growth factor I in 22 children: comparison of two dosage levels and to GH-treated GH deficiency

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One of the reasons is that todays self-injectors, especially single-use pre-filled syringes, have fine needles that cause less pain compared to vaccination or blood draw needles, according to Lake