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651,652 Similarly, CR-boosted NAD + level protects the brain against aging and diseases through attenuating plasma membrane lipid peroxidation, protein carbonyls, nitrotyrosine and oxidative stress

doi: 10.1210/en.2012-1558 38 YoungCDLewisASRudolphMCRuehleMDJackmanMRYunUJet al

1993, 265: E31-E35

Both 4-HNE and MDA are extensively studied markers of lipid peroxidation, with MDA recognized as a mutagenic product of lipid peroxidation and 4-HNE recognized as the most toxic product of lipid oxidation (104), worsening the damage resulting from oxidative stress (105, 106)

doi: 10.3389/fimmu.2023.1123841 62 ZainullinaLFYamidanovRSVakhitovVAVakhitovaYV