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Early studies in obese individuals showed some reductions in body fat mass, but findings are not consistent across trials: In one clinical trial, AOD9604 did not demonstrate statistically significant weight loss compared to placebo, suggesting its fat-burning effects may be modest without lifestyle intervention (summary of trials)

Safety evaluation of AOD9604, a synthetic peptide for use in obesity

13 Journal of Medicinal Chemistry (ACS)Bisubstrate inhibitors of NNMT with enhanced activity

Important limitations you should know For people with normal B12 levels, the evidence is far less compelling