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For chronic conditions, the timeline is longer: early gains within 12 weeks, gradual functional improvement over 48 weeks, major progress within 812 weeks, and best results often after 12+ weeks

These processes are central to recovery because connective tissues such as tendons and ligaments receive limited blood supply and often heal slowly

This means the B12 component in a compounded semaglutide formulation is most likely to help patients who are deficient or at risk of deficiency, those eating very little, those following plant-based diets, older adults whose B12 absorption decreases with age, or those with conditions affecting B12 absorption like gastric bypass or certain GI conditions