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By contrast, tesamorelin's N-terminal trans-2-hexenoic acid modification addresses a different problem: GHRH has a short half-life in vivo due to dipeptidyl peptidase IV cleavage at the Tyr1-Ala2 bond
Paurobally et al., Br J Dermatol 164:14035, 2011, PMID 21564053)
Smaller needles like 31G or 32G might cause even less pain but are harder to handle and can become blocked more easily
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