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The standard approach follows a four-week ramp-up schedule: Week 1: One tablet (8mg naltrexone / 90mg bupropion) in the morning Week 2: One tablet in the morning, one in the evening Week 3: Two tablets in the morning, one in the evening Week 4 onward (maintenance): Two tablets in the morning, two in the evening The full contrave dose for weight loss at maintenance is four tablets per day two in the morning, two at night

Biol (Basel) (2020) 10:18