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The strongest limitation is directness: most claims are extrapolated from native IGF-1, from nonhuman models, or from in-vitro assays using LR3 as a tool
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But direct GH therapy, while tempting, doesn't come without its own set of challenges
Other promising compounds are French maritime pine bark extract62,63 and marine complexes.70 The Future of Systemic Treatments for Skin Aging Cellular senescence, which is characterized by cell cycle arrest and changes in the epigenome, transcriptome, proteome, and secretome, is attracting increasing attention in the setting of skin aging
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