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[15] Methodological issues with the clinical trials prevent firm conclusions, and the review authors stated: "No definitive conclusion can currently be drawn" and there is "no definitive evidence that MSM is superior to placebo in the treatment of mild to moderate osteoarthritis of the knee." [16] Contraindications and safety [edit] In July 2007 a manufacturer of MSM submitted a notification to the U } : CS1 maint: DOI inactive as of July 2025 (link) Oyo Yakuri Pharmacometrics
Because ipamorelin selectively stimulates GH without affecting cortisol or prolactin, the hormonal side-effect burden is lower than older GHRP compounds
doi: 10.1371/journal.pone.0251135 149 GonzalezDEForestoRDRibeiroAB
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