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Patients with Significant Visceral Adiposity and Cardiovascular Risk: Tirzepatide's disproportionate VAT reduction is specifically relevant for patients whose primary cardiometabolic risk driver is visceral fat patients with central obesity, elevated triglycerides, low HDL, elevated fasting glucose, and hypertension meeting metabolic syndrome criteria
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It affects concentration, vial longevity, waste, and cost efficiency
These include very long term effects beyond ten years, outcomes in younger populations who may use GLP-1s for decades, effects on bone health in older adults, and rare side effects that may only appear with widespread use over time
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