Furthermore, insulin resistance (IR) and chronic hyperglycemia (CH) associated with diabetes exacerbate mitochondrial damage by increasing the production of reactive oxygen species (ROS) within mitochondria
A recent study found that NRF1 can also regulate GPX4 [12]
Melasma appears as symmetrical patches, while hyperpigmentation can appear in spots, streaks, and patches
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Furthermore, the DML c is situated within regulatory regions that contain binding sites for EZH2, CTCF, GPS2, and TCF21 across various cell types 63