Levels decline with age, stress, and environmental exposure
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In this study, we investigated the role of ferroptosis in renal interstitial fibrosis in vivo and in vitro
[4] Perhaps the most notable role of glutathione is how it supports detoxification.* Specifically, glutathione is essential for phase II detoxification, which acts directly on the harmful substances within the body that have been partially broken down in phase I, like heavy metals.* This process is called conjugation and is made possible by glutathione.* These four functions of glutathione are only some examples of the critical roles it plays in the body.* There are several contributing factors that may lead to depleted levels of glutathione, such as harmful substances within the body, everyday stress, genetics, overuse of alcohol or other substances, smoking, as well as aging

Methods: In a prospective, multicentric cohort study in two large PC practices in Belgium between October 2020 and May 2023, a FibroScan measurement (for assessment of steatosis by CAP and of LSM as a surrogate for fibrosis) and clinical examination (waist circumference (WC) and BMI) was performed at baseline and follow-up