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Catalytic modification of the C-8 and C-14 hydroxyl groups also resulted in significant activity attenuation, suggesting that the intramolecular hydrogen-bonding network in this region is essential for conformational stability (Wang et al., 2012b)
Nutrients , 10 (4), 400
doi: 10.1097/MD.0000000000017600 330 MeeusMGoubertDDe BackerFStruyfFHermansLCoppietersIet al
[] SFN also suppresses the Akt signaling cascade, which is associated with cancer progression, inhibits the chemokine receptor CXCR4, and enhances the functionality of natural killer
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