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This was a specific and unexpected side effect, reported by a large percentage of patients, and, again, less likely to be a placebo effect

Dihexa was originally designed for Alzheimers, and may support early interventionthough its not a cure

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By activating downstream signaling pathways, IL-1 reduces the expression of key tight junction proteins, such as occludin and claudin-5, in BBB endothelial cells (101)