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3g, GS siRNA transfection, which led to more than 60% GS gene silencing, similarly increased the sensitivity of hepatocytes to TNF killing, suggesting that increased GSSG accumulation mechanistically contributed to cellular glutathione imbalance-induced susceptibility to TNF-induced cell death
Acta 3 ArosioP.LeviS
However, the importance of its function is still questionable because of the low plasma concentration of glutathione (33)
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