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doi:10.1016/j.archger.2007.03.012
The noncanonical pathway is stimulated by cytokines such as CD40L or BAFF, involving NIK-mediated processing of p100 to p52 and formation of RelB/p52 dimers that translocate into the nucleus
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In a 2003 in vitro experiment by Khavinson and colleagues, addition of micromolar concentrations of the peptide to cultured human somatic fibroblasts produced a measurable increase in telomerase reverse transcriptase activity and a corresponding extension of telomere length across 1020 passages, with cell cultures continuing to divide beyond the Hayflick limit observed in untreated controls
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