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A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity

1 To understand whether non-diabetic patients prescribed GLP-1 medications experience similar rates of these gastrointestinal (GI) side effects, we studied 367,439 non-diabetic patients, including 170,842 who were on a GLP-1 medication and 196,597 who were on other weight loss medications

Gastrointestinal effects Nausea is the most common side effect, affecting roughly 41% of participants in the REDEFINE 1 trial

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doi: 10.4049/jimmunol.128.1.337 37 YooHSMaheswaranSKLinGTownsendELAmesTR