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Briefly, cultured SKOV-3 cells were pre-incubated with DCFH-DA (20 M) in culture medium for 30 minutes, washed twice with PBS, and treated with increasing concentrations of AuP NPs up to 72 hours

Upon neuronal depolarization, methylnorepinephrine is released into the synaptic cleft, where it preferentially activates presynaptic 2adrenergic receptors rather than postsynaptic 1receptors ( panel 4 )