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This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery

Because melanonychia is typically difficult to diagnose clinically, a biopsy is usually required to rule out melanoma

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Ozempic and Wegovy belong to a class of drugs called glucagon-like peptide-1 (GLP-1) agonists