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Clinical trials indicate that gastrointestinal adverse effects are commonly experienced and severe hypoglycemia is rare
In parallel, the reduction in glycemic burden induced by GLP-1 activity creates a metabolic milieu that may restore GIPR sensitivity and functionality
It is important to note that Ozempics weight loss effects are significant but not as pronounced as those of Wegovy, which is specifically approved for weight loss
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However, it was not possible to obtain the initial results again, and this compound was also excluded from clinical trials ( in vitro , so its activity may be due to other mechanisms of action (Maples et al., 2001)
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