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With the inward conformation of the 2-helix in AtDHAR2, uncoiling of the 1-helix is not possible which would reorient the Asp19 side-chain into the active site due to inevitable steric interference of the N-terminal loop of the 2 hinge region
It usually starts in the rectum and can spread upward in a continuous pattern
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This can reduce the speed at which glucose enters the bloodstream and can also increase fullness after eating
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