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Rather than viewing complexity as an inherent liability, contemporary pharmacology increasingly recognizes that pleiotropic signaling can be therapeutically advantageous when appropriately modulated through dosing, bias, and patient stratification ( 7.1 Phoenixin: integrating metabolism, reproduction, and affect Phoenixin is a relatively recently described neuropeptide identified through bioinformatic analysis of conserved peptide sequences and expressed in both central and peripheral tissues
Modern research attributes excessive adiposity to dysfunctions in satiety hormone signaling and central nervous system (CNS) feeding centers (10)
Every patient begins with a comprehensive consultation to review health history, goals, and eligibility for GLP-1 therapy
Koehler JA, Kain T, Drucker DJ
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