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Methods Participants This study was conducted in accordance to the Declaration of Helsinki, and the protocol was approved by the ethics committee of the Gunma University Graduate School of Medicine (Approval number HS2018-140)
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In conclusion, multi-targeted nanomedicine delivery systems hold strong preclinical potential to provide a novel framework for advancing osteosarcoma treatment by precisely modulating the TME and eliciting durable antitumor immune responses
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