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Cellular metabolic basis of altered immunity in the lungs of patients with COVID-19

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Research has shown that vitamin D deficiency or insufficiency contributes to the seasonal nature of cold and flu outbreaks less sunlight means less vitamin D production in the skin, which is linked to lower immunity and the possibility of more illness

This suggests that ChREBP and downstream associated transcription factors might also play a role in the observed metabolic shift

It is believed that the C-terminal is associated with dimerization and contains docking regions for PDE-selective kinases (Essayan, 2001)