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Heavy metals accumulate in biological tissue and produce confounding effects in long-term studies
A deficiency of Vitamin B12 can lead to advanced anemia where the red cells are fewer in number but are larger than normal (macrocytic)
For instance, a phase II trial in ulcerative colitis patients was mentioned in abstracts
[4] In the SURMOUNT-1 obesity trial, a 72-week placebo-controlled study in 2,539 adults with obesity (without diabetes), mean weight change was 15.0%, 19.5%, and 20.9% at the 5, 10, and 15 mg doses versus 3.1% for placebo
Given the theoretical cancer concern (disrupting senescence surveillance) and absence of human pharmacokinetic data, caution is warranted
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