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This gel can soften stools and add bulk to them, which helps in the management of constipation and diarrhea, says Julia Zumpano, a registered dietitian with the Cleveland Clinic Center for Human Nutrition

Of importance: this study did not manipulate diet or use any other gut-healing agents

This trifecta approach represents a leap forward in understanding how multiple hormonal signals can be harmonized to treat complex metabolic dysfunction

Discuss your weight management goals with your GP, who will assess your metabolic health, check for contraindications (particularly renal function), and determine whether metformin is suitable as part of a comprehensive approach including dietary modification and increased physical activity

ADA Standards of Care 2025.