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This has slowed to 45 days by the time a person is in their 40s, and it keeps slowing as they become older
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In addition, ATAC-seq analysis revealed that Hb promoter accessibility is increased at D1 and subsequently reduced by D3 under chronic H 2 O 2 exposure, indicating early activation followed by epigenetic suppression during prolonged stress
The reason he calls this a hypothesis, is that even though many studies (some you will see below) have demonstrated this effect, there have not been enough large-scale randomized trials to definitively prove this out
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