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Real-world cases and clinical guidance show that such measures make a big difference in comfort levels for IBS patients on GLP-1 therapy
The ensuing negative feedback loop may involve not only EECs but also Paneth cells and intestinal intraepithelial lymphocytes, as these cells have been reported to express the receptor for GLP-1 (namely GLP-1R), and loss of GLP-1R increases the severity of DSS-induced intestinal injury8, 9
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10.1210/clinem/dgaa891 31 RahbariR.ZhangL.KebebewE
When a patient attempts to engage in physical or cognitive exertion, they demand ATP that simply isn't available, triggering a severe metabolic crash known as post-exertional malaise (PEM)
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