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Derynck, R., Turley, S
(Middle) Upon reaching the tumor site, these nanocarriers exert their therapeutic effects through three primary mechanisms (1): Macrophage Reprogramming, where the delivery of immunomodulators (e.g., TLR agonists) converts tumor-promoting, anti-inflammatory M2 macrophages into tumor-suppressive, pro-inflammatory M1 macrophages
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