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Adhering to this distinction is fundamental for maintaining ethical research standards and regulatory compliance
While well-tolerated, they require careful consideration of potential adverse effects and contraindications (6)
The reasons: Low lower limit : In most countries, the lower end of the standard vitamin B12 range (100-250 pg/mL) is too low, often missing severe deficiencies
While melatonin in the UK requires a prescription, in the US it is freely available over the counter, and found on shelves next to vitamin supplements
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