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The PANTHER trial (IPFnet) compared NAC, combination therapy (prednisone + azathioprine + NAC), and placebo in 236 patients (138)

[] When the impact of NAC on biochemical indicators of inflammatory processes was further examined, blood levels of C-reactive protein (CRP), tumour necrosis factor-alpha, IL-10, IL-6, IL-8 and brain-derived neurotrophic factor (BDNF) showed no significant changes

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