Losing primarily fat while preserving lean muscle mass produces far better outcomes than losing a proportional mix of both
10.3389/fnagi.2010.00012 Front
Now this same energy, ATP energy, NAD energy is being used in thousands of chemical reactions that happens every single day
By reducing adipose tissue mass, improving lipid profiles, and enhancing mitochondrial function, NNMT inhibition addresses multiple pathways involved in metabolic syndrome development
protein misfolding, mislocalization of TDP-43 to the cytoplasm, ER stress, inhibition of ER-Golgi transport, and apoptosis, in neuronal cells expressing pathological forms of TDP-43 or SOD1 (Parakh et al., 2020)