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High concentrations of GH and subsequent insulin-like growth factor-1 (IGF-1) can adversely affect insulin sensitivity and stimulate unwanted pathways associated with cell proliferation

The composition of the commensal microbiota might allow the prediction of weight gain in human individuals at risk like pregnant women [233]

Maintenance planning therefore begins before discontinuation rather than after regain starts

BPC-157 is described as well tolerated and without demonstrated toxicity in rodents, but the human safety dossier is unpublished, and over 80 percent of the literature comes from a single research group, so independent replication is limited Sikiric et al., 2025