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Eating late can also make lying down uncomfortable
However, that is both Wegovy 7.2mg and CagriSema (2 assets) that are competitive to Tirzepatide SURMOUNT-1 data as a placebo-adjusted weight loss of -20.1% and likely to be in commercialisation in the US in 2026 and early 2027
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The Lys-34 to Arg-34 substitution is structurally subtle but functionally critical: it removes the native lysine at position 34, ensuring that the fatty-acid moiety attaches selectively to Lys-26 and not to the alternative position
BMC Pharmacol Toxicol 27 , 53 (2026)
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