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Description

In hereditary or acquired metabolic defects, an initial intravenous bolus of 50 mg/kg may be administered over two to three minutes, followed by maintenance doses of 50 mg/kg every six hours or continuous infusion to achieve a total daily exposure of up to 300 mg/kg in critical illness

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There were 12 serious AEs (SAEs) (11 SAEs and one SUSAR) in the trial (Table 4)

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