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Before initiating treatment with GLP-1 receptor agonists, healthcare professionals should consider obtaining baseline liver function tests (LFTs) , including ALT, AST, alkaline phosphatase (ALP), and bilirubin, particularly in patients with risk factors for liver disease

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To ensure the efficacy of semaglutide for weight management, additional research was conducted, including the STEP (Semaglutide Treatment Effect in People with Obesity) clinical trial program

Tallman DL, Taylor CG